ActionsCite Favorites Display options Display options Format 1 Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. 1 Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Noroviruses (NoVs) and rotaviruses (RVs), the two most important causes of viral acute gastroenteritis, are found to recognise histo-blood group antigens (HBGAs) as receptors or ligands for attachment. Human HBGAs are highly polymorphic containing ABO, secretor and Lewis antigens. In addition, both NoVs and RVs are highly diverse in how they recognise these HBGAs. Structural analysis of the HBGA-binding interfaces of NoVs revealed a conserved central binding pocket (CBP) interacting with a common major binding saccharide (MaBS) of HBGAs and a variable surrounding region interacting with additional minor binding saccharides. The conserved CBP indicates a strong selection of NoVs by the host HBGAs, whereas the variable surrounding region explains the diverse recognition patterns of different HBGAs by NoVs and RVs as functional adaptations of the viruses to human HBGAs. Diverse recognition of HBGAs has also been found in bacterial pathogen Helicobacter pylori. Thus, exploratory research into whether such diverse recognitions also occur for other viral and bacterial pathogens that recognise HBGAs is warranted. Tan M, et al. Trends Microbiol. 2011 Aug;19(8):382-8. doi: 10.1016/j.tim.2011.05.007. Epub 2011 Jun 24. Trends Microbiol. 2011. PMID: 21705222 Free PMC article. Yang Y, Xia M, Tan M, Huang P, Zhong W, Pang XL, Lee BE, Meller J, Wang T, Jiang X. Yang Y, et al. J Virol. 2010 Sep;84(18):9595-607. doi: 10.1128/JVI.02614-09. Epub 2010 Jun 30. J Virol. 2010. PMID: 20592096 Free PMC article. Ruvoën-Clouet N, et al. Rev Med Virol. 2013 Nov;23(6):355-66. doi: 10.1002/rmv.1757. Epub 2013 Aug 20. Rev Med Virol. 2013. PMID: 23959967 Huang P, et al. J Virol. 2005 Jun;79(11):6714-22. doi: 10.1128/JVI.79.11.6714-6722.2005. J Virol. 2005. PMID: 15890909 Free PMC article. Yi Y, et al. Emerg Microbes Infect. 2021 Dec;10(1):954-963. doi: 10.1080/22221751.2021.1925162. Emerg Microbes Infect. 2021. PMID: 33929932 Free PMC article. Chassaing M, Bastin G, Robin M, Majou D, Belliot G, de Rougemont A, Boudaud N, Gantzer C. Chassaing M, et al. Front Microbiol. 2021 Apr 13;12:662764. doi: 10.3389/fmicb.2021.662764. eCollection 2021. Front Microbiol. 2021. PMID: 33927710 Free PMC article. Xie D, Chen J, Yu J, Pei F, Koroma MM, Wang L, Qiu M, Hou Y, Yu D, Zhang XF, Dai YC. Xie D, et al. Front Microbiol. 2020 Dec 8;11:607723. doi: 10.3389/fmicb.2020.607723. eCollection 2020. Front Microbiol. 2020. PMID: 33363528 Free PMC article. Liu C, et al. Vaccine. 2021 Jan 8;39(2):263-271. doi: 10.1016/j.vaccine.2020.12.005. Epub 2020 Dec 11. Vaccine. 2021. PMID: 33309483